What is Fluoxetine?
Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) class antidepressant. The active pharmaceutical ingredient is formulated as Fluoxetine hydrochloride and is globally recognized by the brand name "Prozac." Originally developed by Eli Lilly and introduced to the market in the 1990s, it is prescribed for the treatment of major depressive disorder in adults, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder—with or without agoraphobia. It delivers potent antidepressant effects and is routinely used as a first-line therapeutic agent due to its proven efficacy and favorable tolerability profile.
The primary mechanism of action involves the selective blockade of presynaptic neuronal reabsorption of serotonin (5-HT) in the central nervous system. This selective inhibition enhances serotonergic transmission, providing relief from depressive symptoms. Unlike many other agents, Fluoxetine exhibits minimal affinity for various receptor types, including alpha-adrenergic, beta-adrenergic, serotonergic (excluding 5-HTT), and dopaminergic receptors, which contributes to its improved side effect profile.
Upon oral administration, Fluoxetine is efficiently absorbed through the gastrointestinal tract, with peak plasma concentrations reached in approximately 6 to 8 hours. It demonstrates extensive plasma protein binding (around 95%) and widespread distribution throughout the body. Steady-state concentrations are typically reached after several weeks of continuous use. The compound undergoes hepatic metabolism, primarily via demethylation, to form an active metabolite—norfluoxetine (demethylfluoxetine)—which also contributes to the therapeutic effect.
The elimination half-life of the parent compound, Fluoxetine, ranges from 4 to 6 days, while that of norfluoxetine extends between 4 to 16 days, resulting in a prolonged duration of action. Excretion is predominantly renal, although the drug is known to pass into breast milk. As a precaution, clinical use in pregnant and breastfeeding women requires careful evaluation and professional guidance to mitigate potential infant exposure.
Synonyms
(+/-)-N-methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine; METHYL-[3-PHENYL-3-(4-TRIFLUOROMETHYLPHENOXY)PROPYL]AMINE; AURORAKA-7692; FLUOXETINE; (±)-benzenepropanamine; (+) or (–)-N-methyl-3-phenyl-3-((α,α,α-trifluoro-p-tolyl)oxy)propan-1-amine; (+) or (–)-N-methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine; dl-3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
Product Specification
Product Name:
Fluoxetine
CAS No.:
54910-89-3
Molecular Weight:
309.33 g/mol
EINECS:
611-209-7
Chemical Formula:
C₁₇H₁₈F₃NO
Boiling Point:
395.1 ± 42.0 °C (Predicted)
Density:
1.159 ± 0.06 g/cm³ (Predicted)
pKa (Acidity Coefficient):
10.05 ± 0.10 (Predicted)
Applications
A pioneering antidepressant that selectively blocks the presynaptic reuptake of serotonin (5-hydroxytryptamine, 5-HT). Due to its long half-life and that of its primary metabolite, it maintains steady plasma levels over extended periods, particularly after chronic administration. It displays minimal off-target receptor interactions, resulting in low toxicity. It is indicated not only for major depression but also for conditions such as obsessive-compulsive disorder (OCD). Due to its anxiolytic properties, it is highly effective in treating depression associated with anxiety symptoms.
Packaging & Delivery
- For 1–20 kg: Sealed in foil bags and placed in a master carton, shipped via express courier.
- For 20–25 kg: Packaged in fiber drums or master cartons, shipped by express.
- Orders over 100 kg: Can be dispatched via sea freight to reduce shipping costs.
FAQ
Can I receive a complimentary sample?
Yes, we provide a free sample of Fluoxetine powder upon request. The recipient is responsible for covering the shipping cost.What payment methods do you accept?
We support payment through T/T (Telegraphic Transfer), Credit Card, Western Union, and PayPal.How do you ensure product quality?
We follow a strict, proven quality management system. Final product testing is conducted prior to dispatch to guarantee compliance and prevent any quality issues.Do you offer OEM services?
Yes, we welcome OEM manufacturing requests.How can I get in touch with your team?
Please use email, Skype, or WhatsApp to reach us.
We supply a wide range of active pharmaceutical ingredients (APIs) tailored to customer needs. For further details or any inquiries about Fluoxetine or other products, please contact us at:
[email protected]
