An Overview of Azithromycin
Azithromycin is a clinically prevalent antibiotic known for its broad-spectrum efficacy, minimal gastrointestinal irritation, and rapid oral absorption. It is suitable for both adults and children and stands among the most widely prescribed antibiotics for bacterial infections due to its milder side effect profile compared to cephalosporins. As a second-generation semi-synthetic macrolide, Azithromycin differs structurally from erythromycin by incorporating a methyl-substituted nitrogen at the 9a position of the erythromycin lactone ring, resulting in a 15-membered macrolide structure.
Synonyms
- 10% aqueous Azithromycin
- 70% water-soluble Azithromycin
- N-METHYL-11-AZA-10-DEOXO-10-DIHYDROERYTHROMYCINA
- 11-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-3,4,10-tr
- 11-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-2-ETHYL-3,4Chemicalbook,10-TRIHYDROXY-14-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-3,5,6,8,10,12,13-HEPTAMETHYL-1-OXA-6-AZA-CYCLOPENTADECAN-15-ONE
- 9-DEOXO-9ALPHA-METHYL-9ALPHA-AZA-HOMOERYTHROMYCINA
- 9-deoxo-9a-methyl-9a-aza-homoerythromycina
- AZITHROMYCIN
Product Specifications
- Product Name: Azithromycin
- CAS NO.: 83905-01-5
- Molecular Weight: 748.98
- EINECS: 617-500-5
- Formula: C₃₈H₇₂N₂O₁₂
- Density: 1.18±0.1 g/cm³
Mechanism of Action
Azithromycin functions similarly to erythromycin by targeting the 50S subunit of bacterial ribosomes to inhibit RNA-dependent protein synthesis, retaining erythromycin’s antibacterial profile. While its activity against Chlamydia mirrors erythromycin, it exhibits significantly stronger efficacy against Gram-negative bacteria, including:
- Influenza bacillus & Neisseria gonorrhoeae: 4× more potent than erythromycin
- Legionella: 2× more active than erythromycin
- Enterobacteriaceae: Marked improvement over erythromycin
Its MIC for most Gram-negative pathogens is below 1μg/ml. It also demonstrates effective action against Toxoplasma and Treponema pallidum. Notably, Staphylococcus aureus and Streptococcus pyogenes may show cross-resistance to erythromycin.
Azithromycin is primarily indicated for infections of the respiratory tract, urogenital tract, skin/soft tissues, and select sexually transmitted diseases caused by susceptible microorganisms.
Applications
Azithromycin is effective against the following conditions:
- Respiratory Infections: Acute pharyngitis, tonsillitis (caused by Streptococcus pyogenes), sinusitis, otitis media, bronchitis (acute/chronic).
- Pneumonia: Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae.
- Urogenital Infections: Chlamydia and non-drug-resistant Neisseria gonorrhoeae (urethritis, cervicitis, pelvic inflammatory disease). Simple gonococcal genital infections (excluding Treponema co-infections) also respond well.
- Dermal/Soft Tissue Infections: Caused by sensitive bacteria.
Packaging & Delivery
| Cargo Weight | Packaging | Shipping Method | Lead Time |
|---|---|---|---|
| 5–50kg | Foil bag (<5kg); two-layer PP bag (5–25kg), then carton/drum | International Express | 7–10 days |
| 100–200kg | 25kg/drum, two-layer PP bag + cardboard drum | Air Shipping | 7–10 days |
| 500kg+ | 25kg/drum, two-layer PP bag + cardboard drum | Sea Shipping | 20–45 days |
FAQ
- Sample Availability: Free Azithromycin samples are available; shipping costs apply.
- Payment Terms: T/T, Credit Card, Western Union, PayPal, among others.
- Contact Options: Reach us via email or WhatsApp, or call our team directly.
For raw ingredient inquiries, contact Extract Makers at [email protected].
