Product Overview
This compound is derived from the dehydration of sorbitol and functions as an osmotic diuretic for oral use. Its mechanism of action is comparable to intravenously administered mannitol and sorbitol. By elevating plasma osmotic pressure, it draws fluid from tissues (including ocular, cerebral, and cerebrospinal compartments) into the bloodstream. This process effectively reduces tissue edema, lowers intraocular and intracranial pressure, and decreases the volume and pressure of cerebrospinal fluid. It serves multiple roles as a pharmaceutical intermediate, an additive in synthetic plastic resins, and a component in animal feed.
Isosorbide dinitrate is a potent, long-acting nitrate medication used to prevent angina attacks and alleviate their symptoms. It functions as a coronary artery vasodilator for the treatment of angina pectoris.
Product Specification
- Product Name: Isosorbide Dinitrate
- Synonyms: 1,4:3,6-Dianhydro-D-glucitol 2,5-dinitrate; Isosorbitol dinitrate; Cardis; Carvanil; Carvasin; [(3S,3aS,6R,6aS)-6-Nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] nitrate
- CAS Number: 87-33-2
- Molecular Formula: C₆H₈N₂O₈
- Molecular Weight: 236.14
- EINECS: 201-740-9
- Category: Chiral Compounds; Nitric Oxide Reagents; Intermediates & Fine Chemicals; Pharmaceuticals
Mechanism of Action
Like other nitrites and organic nitrates, isosorbide dinitrate is metabolized in the body to release nitric oxide (NO). This active intermediate stimulates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A), triggering the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP). The cGMP then activates protein kinase-dependent phosphorylation cascades within smooth muscle cells, ultimately leading to the dephosphorylation of the myosin light chain. This results in calcium ion release, causing smooth muscle relaxation and subsequent vasodilation.
Pharmacokinetics
Following oral administration, absorption of isosorbide dinitrate is nearly complete. However, its bioavailability is highly variable, ranging from 10% to 90%, due to significant first-pass metabolism in the liver. The average oral bioavailability is approximately 25%.
Packaging & Delivery
- 1-20 kg: Packed in foil bags within master cartons, shipped via express courier.
- 20-25 kg: Packed in drums or master cartons, shipped via express courier.
- Over 100 kg: Available for shipment by sea.
Frequently Asked Questions
Can I obtain samples?
Yes, we provide complimentary samples. The shipping cost will be borne by the client.What are the payment methods and terms?
We accept payments via bank transfer, credit card, Western Union, PayPal, and other methods.How is product quality assured?
Our facility brings over a decade of experience in the industry, supported by mature quality control procedures. Every shipment undergoes rigorous final inspection.Do you offer OEM services?
Yes, we accept OEM orders. Please contact us with your specific requirements. We will provide a competitive quote and produce samples promptly.How can I contact you?
You can reach us via email, Skype, or WhatsApp. Please send your inquiries, and our contact details are available on our website.
Extract Makers is dedicated to providing a wide range of API materials. For any questions or further information, please contact us at: [email protected]
