Introduction of Ezetimibe Powder
Ezetimibe is a white crystalline powder, readily soluble in ethanol, methanol, and acetone, but insoluble in water. It has a melting point of approximately 163℃ and remains stable under ambient conditions. Ezetimibe functions exclusively in the small intestine, where it suppresses cholesterol absorption by inhibiting its transport into the liver, thereby reducing hepatic cholesterol storage. By limiting intestinal uptake, it promotes enhanced clearance of cholesterol from the bloodstream, leading to a significant reduction in plasma cholesterol levels.
Synonym
(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; Ezetimibe-001; Ticagrelor and its intermediate; Ezetimibe 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one; Ezetimibe; Zetia/Vytorin; SCH60969; Ezetimibe, ≥99%
Product Specification
| Product Name: | Ezetimibe powder | CAS NO.: | 163222-33-1 |
| Molecular weight: | 409.43 | EINECS: | 682-606-0 |
| Formula: | C24H21F2NO3 | Density: | 1.334±0.06 g/cm3(Predicted) |
Function
Upon oral administration, ezetimibe is absorbed in the intestine and rapidly conjugated with glucuronic acid to form the pharmacologically active metabolite — ezetimibe glucuronide. This metabolite is primarily eliminated via bile and renal excretion. After oral dosing, peak plasma concentrations are attained within 4 to 12 hours, with Cmax values ranging from 3.4 to 5.5 mg/mL. The compound exhibits a bioavailability of 35% to 60% and a half-life (t1/2) averaging 22 hours.
Ezetimibe primarily targets exogenous cholesterol (dietary intake and biliary secretion), differing from statins, which primarily inhibit endogenous cholesterol synthesis in the liver. This complementary mechanism results in a synergistic lipid-lowering effect. When ezetimibe is administered in combination with a statin, cholesterol reduction is up to eight times greater than with statin monotherapy.
Packaging & Delivery
| Cargo weight | Packing | Shipping method | Lead-time |
| 5-50kg | Below 5kg Use Foil bag;5-25kg use two layer PP bag,then into master carton or cardboard drum | International express | 7-10days |
| 100-200kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Air shipping | 7-10days |
| Over 500kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Sea shipping | 20-45days |
Standard packaging is 25 kg per drum. Orders exceeding 50 kg are eligible for air freight, while orders over 100 kg may be shipped by sea.
FAQ
1. Can I receive a sample at no cost?
Yes, Extract Makers provides complimentary sample quantities of Ezetimibe powder for evaluation. The customer is responsible for covering all shipping expenses.
2. What are the available payment methods and terms?
Accepted payment options include Bank Transfer (T/T), Credit Card, Western Union, PayPal, and other secure methods. Payment terms vary depending on order size and client relationship.
3. How does Extract Makers ensure product quality?
With over a decade of specialized experience in the field, Extract Makers has established a robust quality management system. Every batch undergoes rigorous in-process and final quality checks prior to shipment to ensure consistency, purity, and compliance.
4. Do you offer OEM services?
Yes, Extract Makers welcomes OEM requests. Please get in touch with your product specifications or branding requirements, and we will provide a competitive quote and develop tailored samples as soon as possible.
5. How can I contact Extract Makers?
You can reach us via email, Skype, WhatsApp, or instant messaging platforms. Alternatively, place a direct phone call or send us a message through our website’s contact section.
Extract Makers supplies a comprehensive range of active pharmaceutical ingredients (APIs) for global customers. For further details, technical specifications, or pricing inquiries, please feel free to contact us via email: [email protected].
