What is Cordycepin?
Cordycepin, also referred to as 3′-deoxyadenosine, is a naturally occurring nucleoside compound with the chemical formula C10H13N5O3. It was the first nucleoside antibiotic ever isolated from fungal sources. Known for its broad-spectrum bioactive properties, cordycepin has become a subject of intense scientific interest since its discovery.
In the 1950s, wild Cordyceps militaris was identified in the Changbai Mountain region of Jilin, China. Research revealed that the active constituents in this species are significantly more potent than those found in wild Cordyceps sinensis, leading to its widespread recognition as a superior alternative. In 1951, German researchers Cunningham and colleagues isolated cordycepin as the primary bioactive compound in Cordyceps militaris. They demonstrated its diverse pharmacological activities, including powerful antimicrobial, anti-inflammatory, antiviral, antitumor, and immunomodulating effects.
Over the following decades, extensive research expanded the understanding of cordycepin’s potential. By 1997, cordycepin had advanced to Phase III clinical trials in the United States for the treatment of pre-B and pre-T cell acute lymphocytic leukemia. Then, in 2017, Professor Wang Chengshu of the Chinese Academy of Sciences published groundbreaking findings on Cordyceps militaris in Cell Chemical Biology—a journal under the Cell press—revealing the complete biosynthetic mechanism of cordycepin. Notably, this study also disclosed, for the first time, the fungus’s ability to produce pentostatin, a compound that protects cordycepin from degradation by stabilizing its structure—highlighting a unique self-preserving biosynthetic pathway.
Product Specification
| Product Name: | Cordycepin | CAS NO.: | 73-03-0 |
| Molecular weight: | 251.24 | EINECS: | 200-791-4 |
| Formula: | C10H13N5O3 | Density: | 1.2938±0.1 g/cm3(Predicted) |
Function
Antitumor Activity of Cordycepin:
Modern research categorizes cordycepin’s antitumor mechanisms into two primary modes: direct and indirect action. The direct pathway involves the compound’s interference with critical cellular processes—such as nucleic acid replication, protein synthesis, and glucose metabolism—thereby inhibiting tumor cell proliferation. It triggers autophagy and apoptosis through multiple signaling pathways. Indirectly, cordycepin strengthens immune responses by stimulating the proliferation and differentiation of human immune cells, enhancing the body’s natural defense against cancer.
Antiviral Properties of Cordycepin:
As one of the first nucleoside antibiotics identified, cordycepin exhibits strong inhibitory effects against a wide range of pathogens, including bacteria, fungi, and viruses—making it a valuable candidate for antiviral development.
Anti-Aging Effects of Cordycepin:
Studies show cordycepin boosts the activity of the antioxidant enzyme SOD in the liver, helping neutralize oxidative stress. It also elevates monoamine oxidase activity in the brain, supporting neuroprotective and anti-aging effects, indicating significant potential in age-related degeneration.
Blood Lipid Reduction and Anti-Thrombotic Effects:
Cordycepin enhances spleen function, accelerates the turnover of hepatic nucleic acids and proteins, improves resistance to anoxia, increases blood perfusion to the heart, lowers serum cholesterol, and inhibits clot formation—making it beneficial for cardiovascular health.
Anti-Inflammatory and Immunomodulatory Effects:
Substantial scientific literature confirms that cordycepin holds robust immunomodulating, anti-inflammatory, antimicrobial, and antitumor properties. It also shows promise in mitigating oxidative damage, metabolic dysfunction, and neurodegenerative disorders. While its precise mechanisms remain partially complex, its biological activity is firmly established in the scientific community. Moreover, emerging evidence supports its role in lowering blood glucose levels, managing obesity, improving memory, and slowing aging—positioning cordycepin as an exceptional nutraceutical agent.
Application
Cordycepin is extensively used in pharmaceutical development and functional health supplements, particularly in formulations targeting immune support, cancer prevention, cardiovascular wellness, and cognitive enhancement.
Packaging & Delivery
Standard packaging is 25 kg per drum. For orders exceeding 50 kg, air freight is available; over 100 kg, we offer ocean freight options for more cost-effective delivery.
FAQ
1. Can I receive a free sample?
Yes, we provide free samples of Cordycepin. However, the recipient is responsible for covering shipping costs.
2. What are the available payment terms?
We accept multiple payment methods, including bank transfer (T/T), credit card, Western Union, PayPal, and others.
3. How does your facility ensure product quality?
With over a decade of experience in botanical extraction, our manufacturing process adheres to a strictly refined quality control system. We conduct final inspections before shipment to ensure compliance and consistency.
4. Do you offer OEM services?
Yes, we welcome OEM orders and provide custom labeling and packaging solutions.
5. How can I contact you?
You can reach us via email, WhatsApp, or by a direct phone call. All contact details are available on our official website.
Extract Makers supplies high-purity raw materials for pharmaceutical and nutraceutical applications. If you have any questions or require further technical data, please don’t hesitate to reach out via email: [email protected].
