Clindamycin HCl

Overview of Clindamycin HCl

Clindamycin hydrochloride (HCl) is a potent antibiotic derived from Lincomycin, first registered in our country in the early 1970s. While it shares the same antimicrobial spectrum as Lincomycin, Clindamycin HCl exhibits significantly enhanced antibacterial potency. It is widely utilized in the treatment of various infections, including osteomyelitis, anaerobic bacterial infections, respiratory tract infections, biliary tract infections, endocarditis, otitis media, skin and soft tissue infections, and septicemia.

The most frequently observed side effects associated with its use include allergic responses, localized irritation at injection sites, and transient liver function abnormalities. The most severe and potentially life-threatening adverse reaction is pseudomembranous colitis, typically linked to disruption of normal gut flora.

Synonyms

Clindamycin (base and/or unspecified salts); (2S,4R)-N-[(1S,2S)-2-Chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide; CLDM; Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)-1-methyl-4β-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside; Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside; U-21251; Clindamycin Base; 7-Chloro-7-deoxylincomycin; 7-Chlorolincomycin

Product Specification

Function

Clindamycin HCl exerts its antibacterial effects by binding to the 50S ribosomal subunit in bacteria, effectively halting peptide chain elongation and suppressing protein synthesis. Its antimicrobial profile closely resembles that of erythromycin, demonstrating strong in vitro activity against Gram-positive organisms, including Staphylococcus (including penicillin-resistant strains), Streptococcus, Corynebacterium diphtheriae, and Bacillus anthracis. Additionally, it shows excellent efficacy against Gram-negative anaerobes—most notably Bacteroides species (including B. fragilis), Clostridium, Peptococcus, Peptostreptococcus, and Fusobacterium—all of which are highly susceptible to this compound.

In contrast, Gram-negative aerobes such as Haemophilus influenzae, Neisseria species, and Mycoplasma are generally resistant to Clindamycin HCl.

Application

Clindamycin HCl is indicated for the treatment of infections caused by susceptible Gram-positive and anaerobic bacteria, including:

1. Respiratory tract infections – including acute bronchitis, acute exacerbations of chronic bronchitis, pneumonia, lung abscesses, empyema, anaerobic pulmonary infections, bronchiectasis with infection, suppurative otitis media, and sinusitis.
2. Urinary tract infections – such as acute urethritis, acute pyelonephritis, and prostatitis.
3. Female pelvic and genital infections – including endometritis, nongonococcal tubo-ovarian abscesses, pelvic inflammatory cellulitis, and post-gynecological surgery infections. Often used in combination with aminoglycosides for broader coverage.
4. Skin and soft tissue infections – such as acne vulgaris, furuncles, carbuncles, abscesses, cellulitis, and both traumatic and postoperative wound infections.
5. Bone and joint infections – particularly osteomyelitis (a frontline treatment for Staphylococcus aureus osteomyelitis) and septic arthritis (highly effective in S. aureus-induced cases).
6. Intra-abdominal infections – including peritonitis, intra-abdominal abscesses, and biliary tract infections.
7. Other conditions – such as endocarditis, septicemia, tonsillitis, and oral cavity infections.

Packaging & Delivery

Standard packaging: 25 kg per fiber drum.
For orders exceeding 50 kg: available for air freight.
For orders above 100 kg: suitable for ocean freight.

FAQ

1. Can I place an order online?
Yes, we operate an online ordering system. Simply provide your email address, and we will create the draft order for your review.

2. What are the available payment methods and terms?
We accept T/T, credit card, Western Union, PayPal, and other trusted payment platforms.

3. What is the estimated lead time?
Orders are typically shipped within 3–5 business days after payment confirmation. Please consult with our sales representative to confirm product availability in stock.

4. Are there any discounts available?
Yes, discount options are available for select items, depending on order volume.

5. Do you provide OEM services?
Absolutely. We welcome OEM partnerships. Share your design or specifications with us, and we will provide a competitive quote and expedited sample preparation.

Extract Makers supplies a broad range of active pharmaceutical ingredients, including Clindamycin HCl. If you have questions or need additional product details, feel free to reach out via email: [email protected]

Sarah