What is Chlorpheniramine Maleate?
Chlorpheniramine maleate is an organic compound with the molecular formula C20H23ClN2O4. It is predominantly utilized as a first-generation antihistamine, effective in managing conditions such as allergic rhinitis, dermal and mucosal hypersensitivities, and alleviating common cold symptoms like watery eyes, sneezing, and nasal discharge. Widely recognized for its rapid onset and reliable action, it remains a trusted ingredient in allergy and cold relief formulations.
Synonym
1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane bimaleate; 1-Para-chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate; 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1); Chlorophenamine; Chlorprophenpyridamine maleate; Cloropiril; Histadur
Product Specification
- Product Name: Chlorpheniramine Maleate
- CAS Number: 113-92-8
- Molecular Weight: 390.86 g/mol
- EINECS Number: 204-037-5
- Chemical Formula: C20H23ClN2O4
- Density: 1.1984 (approximate)
Function
Chlorpheniramine maleate functions as a potent H1 receptor antagonist, belonging to the alkylamine class of antihistamines. Its primary mechanism of action involves competitively inhibiting histamine binding to the H1 receptors on target cells involved in allergic responses. By blocking receptor activation, it prevents the cascade of allergic symptoms without interfering with histamine synthesis, release, or degradation.
In addition to its antihistaminic properties, chlorpheniramine exhibits mild anticholinergic effects and central nervous system depressant activity. Common side effects include drowsiness, dry mouth, constipation, increased mucus viscosity, and dry nasal passages. Despite these, its favorable safety profile—especially in comparison to older antihistamines such as diphenhydramine and promethazine—makes it a preferred choice for daytime use and pediatric applications. It offers a stronger antihistamine effect than these alternatives, while demonstrating a relatively lower degree of sedation and anticholinergic response.
Long-term clinical applications have confirmed that chlorpheniramine has a pronounced anti-allergic action, requires only low dosages, and carries minimal risk of adverse reactions. It also reduces tracheal mucus secretion and gastric acid output. Prior to the development of newer non-sedating antihistamines, chlorpheniramine was a cornerstone therapy in allergy management and remains widely used in combination cold and allergy medications.
Application
Chlorpheniramine maleate is indicated for the treatment of cold symptoms and a broad spectrum of allergic conditions affecting the skin and mucous membranes. It is commonly prescribed for urticaria, eczema, dermatitis, drug rashes, pruritus, neurodermatitis, insect bites, photodermatitis, and allergic conjunctivitis. Additionally, it is effective in the management of vasomotor rhinitis, drug hypersensitivity, and food-induced allergic reactions.
Beyond its competitive blockade of histamine H1 receptors—responsible for its core anti-allergy effect—chlorpheniramine also possesses antagonistic activity against muscarinic (M) receptors. This dual pharmacological profile contributes to its symptom relief capabilities but also explains secondary symptoms such as dry mouth, reduced gastrointestinal motility, thickened respiratory secretions, and nasal dryness after dosing. These effects are moderate and generally well-tolerated, supporting its continued use in a variety of pharma-ceutical formulations.
Packaging & Delivery
| Cargo weight | Packing | Shipping method | Lead-time |
| 5-50kg | Below 5kg Use Foil bag;5-25kg use two layer PP bag,then into master carton or cardboard drum | International express | 7-10days |
| 100-200kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Air shipping | 7-10days |
| Over 500kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Sea shipping | 20-45days |
Shipping Method & Lead Time
- 5–50 kg: International express delivery — 7–10 days
- 100–200 kg: Air freight — 7–10 days
- Over 500 kg: Sea freight — 20–45 days
Standard packaging is 25kg per drum. Shipments over 50kg are eligible for air transport; orders exceeding 100kg can be delivered via sea shipping.
FAQ
1. Is it possible to receive a free sample?
Yes, Extract Makers provides complimentary samples of Chlorpheniramine Maleate. However, shipping fees are the responsibility of the customer.
2. What are the available payment methods?
We accept payments via bank transfer (T/T), credit card, Western Union, PayPal, and other major options.
3. How do you ensure consistent product quality?
With over a decade of experience in pharmaceutical raw material manufacturing, Extract Makers has established a rigorous quality management system. Final inspections are conducted prior to shipment to guarantee conformity with specifications and to prevent any potential issues.
4. Do you support OEM (private label) services?
Yes, we welcome OEM requests and offer customizable packaging and labeling for select partners.
5. How can I contact your team?
You can reach us directly via email, WhatsApp, phone call, or by visiting our official website. Our contact details are prominently displayed online.
Extract Makers is a trusted supplier of high-purity pharmaceutical-grade raw materials. For further information or inquiries about Chlorpheniramine Maleate or other specialty compounds, please contact us at: [email protected]
