Product Introduction
Chlorhexidine diacetate, commonly referred to as chlorhexidine acetate (IUPAC name: 1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] diacetate), is an organic compound with the molecular formula C₂₂H₃₀Cl₂N₁₀·2(C₂H₄O₂) or C₂₆H₃₈Cl₂N₁₀O₄. It appears as a white to off-white crystalline powder, is odorless, and has a distinctly bitter taste. The compound is miscible in ethanol and exhibits limited solubility in water. Its aqueous solution is widely utilized in pharmaceutical applications, particularly for managing vaginal yeast infections (candidiasis) and cervical inflammation, demonstrating potent antimicrobial and disinfectant properties.
Product Function
Chlorhexidine diacetate is a synthetic antiseptic agent with strong antibacterial activity. It is available in both oral and vaginal formulations, each tailored to specific clinical uses and infection types.
Oral Formulation (Solution/Gargle):
Marketed as an oral rinse or antiseptic mouthwash, chlorhexidine diacetate solution is indicated for managing dental and oral mucosal infections. Recommended usage involves gargling for 2–5 minutes after nightly toothbrushing, followed by expectoration—not ingestion. This regimen effectively targets oral pathogens, offering relief in conditions such as mouth ulcers, gingivitis, and post-surgical site disinfection. Swallowing the solution post-gargling is not advised and may compromise treatment efficacy.Vaginal Suppositories or Creams:
Primarily prescribed for gynecological infections, including bacterial vaginosis, trichomonal vaginitis, and mixed aerobic-anaerobic vulvovaginitis, suppositories deliver targeted local antibacterial action. These dosage forms help restore vaginal flora balance and alleviate symptoms like abnormal discharge and discomfort.
As a prescription-only medicine in most jurisdictions, chlorhexidine diacetate should only be administered following a formal medical consultation. Prior diagnosis of a confirmed infectious condition is essential. For optimal outcomes and safety, patients are strongly encouraged to review product labeling thoroughly and consult with a healthcare provider or pharmacist before and during therapy to ensure proper dosing, technique, and duration.
Product Application
- Surgical & Skin Disinfectant:
- Preoperative hand hygiene: Use 0.02% aqueous solution (1:5000 dilution) with 3-minute immersion.
- Surgical field disinfection: Apply 0.5% alcohol-based solution in 70% isopropyl or ethanol, offering iodine-comparable germicidal performance.
- Instrument sterilization: Immerse in 0.1% aqua solution containing 0.5% sodium nitrite for rust prevention. For storage, 0.02% solution with 0.1% sodium nitrite is suitable, refreshed biweekly.
- Wound care: Employ 1% spray or 0.05% rinse for skin or open wound decontamination.
Urological and Gynecological Care:
A combination preparation containing 1.2 mg/mL chlorhexidine gluconate and 0.2 mg/mL metronidazole is used for vaginal irrigation to treat infections caused by bacteria, Trichomonas vaginalis, and mixed flora. Chlorhexidine acts as a broad-spectrum bactericidal agent, while metronidazole provides coverage against anaerobic bacteria and protozoa. Additionally, chlorhexidine diacetate suppositories are formulated to manage trichomonal, anaerobic, or poly-microbial vaginitis.Oral Therapeutics:
Chlorhexidine diacetate-based mouth rinses serve as adjunctive therapy for gingivitis, peri-implantitis, postoperative oral trauma, gingival bleeding, periodontal abscesses, and oral mucosal lesions. They help control plaque formation and reduce microbial load in the oral cavity.Neonatal Incubator Humidification:
Clinical studies show that low-concentration chlorhexidine diacetate solutions (5000 mg/L and 1000 mg/L) used as humidifying fluids in neonatal incubators effectively suppress bacterial colonization. After 24 hours of use, no bacterial growth was observed; contamination rates remained low at 9.62% (48h) and 13.46% (72h), confirming sustained antimicrobial protection.Minor Wound and Skin Infections:
Topical chlorhexidine gluconate ointments are indicated for superficial burns, scalds, traumatic skin wounds, and localized infections. They are also used off-label for managing eczema, acne vulgaris, and mild tinea pedis due to their dual bacteriostatic and anti-inflammatory effects.Hemorrhoidal and Anal Care:
Chlorhexidine diacetate hemorrhoid suppositories are designed for symptomatic and therapeutic management of internal, external, and mixed hemorrhoids. Research indicates their efficacy in reducing postoperative recurrence of anal warts when used as an adjuvant. The formulation includes semi-synthetic glycerides of fatty acids in the base, where chlorhexidine diacetate—a cationic surfactant—exerts a broad-spectrum antiseptic effect by disrupting microbial cell membrane permeability. The compound also contributes to localized hemostasis.Topical Skin Spray:
Chlorhexidine diacetate antiseptic spray provides relief from skin pruritus, erythema, and edema associated with insect bites, heat rash (miliaria), and secondary skin infections. Its non-irritating formulation enables fast, localized treatment.Ophthalmic Use (Compounded):
Reports support the clinical use of 0.05% chlorhexidine diacetate eye drops, buffered with boric acid (pH 5.5–6.5), for treating fungal keratitis. The preparation has demonstrated favorable therapeutic outcomes, low incidence of ocular irritation, and minimal allergic reactions, making it a practical option for prolonged eye treatment regimens.
Delivery & Packaging
Products are routinely packed in foil-lined bags (1 kg per bag) or sealed export-grade HDPE drums (25 kg per drum).
Custom packaging solutions—ranging from unit-dose vials to bulk containers—are available upon request to meet client specifications.
Distribution options include express courier (DHL, FedEx, etc.), air freight, and sea logistics, ensuring global reach with reliable tracking and compliance.
If you have questions regarding bulk orders, technical data, or formulation support for Chlorhexidine Diacetate powder, please contact us via email: [email protected].
