Betahistine

What is betahistine?
Betahistine is a pharmaceutical compound primarily prescribed for Ménière’s disease, a disorder affecting the inner ear. This condition is characterized by episodic attacks of vertigo—a sudden spinning sensation—alongside fluctuating hearing loss, tinnitus (ringing in the ear), and sensations of ear fullness or pressure. The frequency and intensity of these episodes can vary significantly among individuals, impacting day-to-day function and quality of life.

Physical and chemical data
Product name: Betahistine
CAS: 5638-76-6
Molecular formula: C₈H₁₂N₂
Molecular weight: 136.198
Density: 0.984 g/mL at 25 °C (literature)
Melting point: 140–150 °C (degradation range)
Boiling point: 210.9 °C at 760 mmHg
Refractive index: n²⁰/D 1.518 (literature)
Flash point: 96.7 °C
Polar surface area (PSA): 24.92000
LogP (octanol-water partition coefficient): 1.23440

What is betahistine used for?

1. Betahistine is clinically indicated to manage symptoms associated with Ménière’s disease, including vertigo (spinning sensations), dizziness, nausea, tinnitus, and progressive hearing impairment.

2. While the current body of clinical evidence from high-quality trials is limited, existing studies show a consistent trend toward improved control of vertigo attacks, although quantifying the precise degree of benefit remains challenging. Betahistine has demonstrated therapeutic utility in reducing the frequency and severity of vertigo spells.

3. The compound is frequently referred to as betahistine dihydrochloride, especially in its commercial forms due to enhanced solubility and absorption.

   
   

How does betahistine work?
The exact mechanism by which betahistine alleviates Ménière’s symptoms is not fully understood, but it is recognized as a strong histamine H3 receptor antagonist. By blocking H3 autoreceptors, it enhances neuronal release of histamine, a neurotransmitter that may modulate vascular tone and inner ear fluid dynamics. Additionally, betahistine has potential vasodilatory effects on microvascular beds, possibly improving blood flow within the cochlea and vestibular system. Some research suggests that histaminergic pathways influence nerve activity in the inner ear. Despite these proposed mechanisms, the precise physiological pathway remains under discussion, and multiple theories continue to be explored.

Packaging & Delivery

FAQ

1. Can I request a free sample?
   
   Yes, Extract Makers provide complimentary betahistine samples upon request. Please note that all related shipping expenses are the responsibility of the recipient.

2. What are the payment options and terms?
   
   We accept multiple payment methods, including bank transfer (T/T), credit card, Western Union, PayPal, and other secure online gateways. Terms are negotiable based on order size and partnership status.

3. How does Extract Makers ensure consistent product quality?
   
   With over a decade of specialized experience in plant-based and synthetic extract manufacturing, Extract Makers has established a comprehensive quality assurance system. Each batch undergoes rigorous in-house testing, and we conduct final validation before shipping to eliminate any discrepancies or contamination risks.

4. Do you offer OEM services?
   
   Absolutely. We welcome OEM custom manufacturing requests. Simply reach out with your specifications—whether for labeling, formulation, or dosage form—and we will provide a competitive quote and prototype samples quickly.

5. How can I contact Extract Makers?
   
   Our team is easily accessible via email, Skype, WhatsApp, or phone call. All contact details are listed on our official website, allowing you to communicate in the channel most convenient for you.

   
   

We supply a wide range of active pharmaceutical ingredients (APIs) to international customers. If you have further inquiries or need technical documentation, feel free to reach us at: [email protected]

Sarah