Overview of 99% Ketoconazole Powder:
Ketoconazole is an imidazole-class antifungal agent. Its primary mode of action involves disrupting the synthesis of ergosterol—a critical component of fungal cell membranes—by inhibiting specific enzyme pathways. This disruption increases membrane permeability and ultimately suppresses fungal proliferation. Ketoconazole is effective against a broad spectrum of fungal infections, including superficial conditions like ringworm of the skin and nails, vaginal and gastrointestinal candidiasis, as well as systemic mycoses caused by pathogens such as Candida albicans, Coccidioides, Histoplasma, and others.
Chemical and Physical Properties:
| Property | Value |
|---|---|
| Chinese Name | 酮康唑 |
| English Name | Ketoconazole |
| Chemical Formula | C₂₆H₂₈Cl₂N₄O₄ |
| Molecular Weight | 531.431 g/mol |
| Appearance | White to off-white crystalline powder |
| Density | 1.38 g/cm³ |
| Melting Point | 146°C |
| Boiling Point | 753.4°C |
| Flash Point | 409.4°C |
| CAS Number | 65277-42-1 |
| EINECS Number | 265-667-4 |
| UN Number (Dangerous Goods) | 2811 |
| Hazard Symbol | R25 (Toxic if swallowed) |
| Safety Statements | S36 (Wear suitable protective clothing), S45 (In case of accident or if unwell, seek medical advice immediately) |
| Water Solubility | Practically insoluble |
| Other Solubilities | Freely soluble in dichloromethane; soluble in methanol; slightly soluble in ethanol (96%) |
Specifications of 99% Ketoconazole Powder:
| Test | Specification | Result |
|---|---|---|
| Product Name | Ketoconazole | — |
| Appearance | White or nearly white powder | Conforms |
| Solubility | Insoluble in water; freely soluble in methylene chloride; soluble in methanol; slightly soluble in ethanol (96%) | Conforms |
| Melting Range | 148°C – 152°C | 148°C – 150°C |
| Assay (Purity) | 98.0% – 102.0% | 100.11% |
| Heavy Metals | ≤ 0.002% | Conforms |
Mode of Action of 99% Ketoconazole Powder:
Ketoconazole functions as a broad-spectrum imidazole antifungal, exhibiting both fungistatic and fungicidal activity against dermatophytes, yeasts (Candida, Malassezia, Coccus, Cryptococcus), dimorphic fungi, and other fungal species. Its efficacy is lower against molds such as Mucor, Sporothrix schenckii, and certain species within the Dumbosporaceae family. The key mechanism involves selective interference with fungal cytochrome P-450 enzymes, which blocks the formation of ergosterol—a structural cornerstone of fungal cell membranes—leading to compromised membrane integrity and fungal growth arrest.
Applications of 99% Ketoconazole Powder:
Systemic Fungal Infections: Treatment of invasive mycoses including systemic candidiasis, paracoccidioidomycosis, histoplasmosis, coccidioidomycosis, and blastomycosis.
Cutaneous, Hair, and Nail Infections: For use in dermatophyte- or yeast-induced conditions such as dermatomycosis, onychomycosis, candidal paronychia, tinea versicolor, scalp pityriasis, and chronic mucocutaneous candidiasis—particularly when topical therapies are inadequate due to infection depth, location, or extent.
Persistent Vaginal Candidiasis: Indicated for chronic or recurring cases unresponsive to local antifungal treatments.
Immunocompromised Patients: Prophylactic administration in individuals with weakened immune systems—whether due to genetic factors, underlying disease, or immunosuppressive drug therapy—to reduce the risk of opportunistic fungal infections.
Packaging & Delivery:
Our Ketoconazole powder is securely packaged in pharmaceutical-grade containers to ensure stability, purity, and protection from environmental factors during transit. We offer flexible packaging options tailored to customer needs and global shipping standards. Products are shipped via reliable air and sea freight services with full documentation, including COA, MSDS, and customs compliance papers.
Frequently Asked Questions (FAQ):
Q1: Can I order a sample of Ketoconazole powder for testing purposes?
Yes, Extract Makers provides laboratory samples (50–100g) free of charge to qualified clients for preliminary evaluation and quality verification.
Q2: What is the process for placing an order?
Once product specifications and pricing are confirmed, we issue a proforma invoice detailing payment terms and instructions. Orders proceed upon receipt of payment.
Q3: What level of after-sales support can I expect?
We actively monitor your shipment from dispatch to delivery and provide full assistance with customs clearance if required. In the rare event of quality discrepancies, our technical team will partner with you to resolve the issue promptly.
Q4: How quickly will my order ship?
For in-stock items, dispatch occurs within 3 business days of confirmed payment. For large-scale or custom productions, lead times will be communicated during the ordering process.
Q5: Are bulk purchase discounts available?
Absolutely. The larger the order volume, the greater the discount. Contact our sales team for a personalized quote based on your required quantity.
Explore our full range of high-performance antifungal and hair-growth-inhibiting compounds. For inquiries, reach out anytime at:
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